FLY Lady says to start with the kitchen sink if you want to keep your house organized. I have tried this time and time again, but it just wasn't jiving. There are days I don't even see the kitchen until 10 am. Plus I have to let the dishes pile up during the day if the DDs don't empty the dishwasher in the morning.
The place I have been focusing on is my laundry room - and it is working. If I don't let my laundry pile up my whole house stays so much cleaner! It only takes a few minutes, literally, to fold the laundry when it comes out of the dryer, and another few minutes to put it away. But consistently doing it makes such a HUGE difference.
Try it, look around your house at a place that seems to spill out into other places. Then work on keeping it clutter free and clean. Remember, "By small and simple things, shall great things come to pass."